DMD gene homologs
The alignment scores below were found using Homologene and BLAST.
A BLASTn search was performed to identify similar genes to the human dystrophin gene. Due to the extreme length of the dystrophin sequence, the mRNA sequence was used. Below, are the genes found to be most similar to the human dystrophin gene with their respective species, accession numbers, Expectation values, and coverage of the mRNA length.
Below is an alignment retrieved from Homologene that includes the similarity of the human dystrophin gene and protein to homologues in some notable species. Most importantly, the similarity between M. musculus and human dystrophin protein indicates that mice represent a strong animal model for genetic and therapeutic DMD-related experimentation.
References
"BLASTn of Human Dystrophin Gene." BLAST: Basic Local Alignment Search Tool. Web. 27 Feb. 2010. <http://blast.ncbi.nlm.nih.gov/Blast.cgi>.
"Dystrophin Gene: Conserved in Bilateria." Homologene. National Institutes of Health. Web. 25 Feb. 2010. <http://www.ncbi.nlm.nih.gov/sites/entrez?db=homologene>.
"Dystrophin Gene: Conserved in Bilateria." Homologene. National Institutes of Health. Web. 25 Feb. 2010. <http://www.ncbi.nlm.nih.gov/sites/entrez?db=homologene>.
This site was created by Anthony Parendo for an undergraduate Genetics 677 course at the University of Wisconsin-Madison.
